Category: Neuroscience

A Strategic Attack Against Neurological Diseases

Neurological diseases are often multifactorial, brought on by a genetic and environmental tug-of-war and resulting in multifaceted clinical presentations. Such etiological complexity has hindered treatment progress and has necessitated well-thought-out and systematic strategies of attack to mitigate their global burden....

/ September 3, 2019

A Systematic Evaluation of Immune Response and Plaque Microenvironment Variation in Alzheimer’s Disease

Alzheimer’s disease (AD) – the most prevalent form of dementia – is associated with defining histopathological features that include amyloid-beta (Aβ) plaque deposition and tau protein aggregation, accompanied by synaptic loss, neuronal death, and cognitive decline. The neuropathological changes in...

/ August 5, 2019

New Biology-Driven Drug Discoveries Needed for Treating of Alzheimer’s

Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder that affects millions of people worldwide, leaving behind an immense psychological, emotional, and financial burden on patients, caregivers, and healthcare systems. There are no existing therapies to prevent the onset or...

/ June 17, 2019

Q&A with Dr. Gregory Carter: Developing Computational Strategies and the MODEL-AD Consortium

Gregory Carter, Ph.D., is an Associate Professor at The Jackson Laboratory. His work is focused on developing computational strategies using genetic data to understand complex genetic systems. We recently spoke with Dr. Carter about his research and the MODEL-AD consortium....

Meta-analysis of AMP-AD Datasets Defines the Transcriptional Landscape of Alzheimer’s Disease

The Accelerating Medicines Partnership - Alzheimer’s Disease (AMP-AD) Consortium was formed to accelerate the development of diagnostics and therapeutics for this devastating and complex disease. One roadblock to development is the lack of good pre-clinical models, as efficacy in clinical...

/ January 31, 2019