Category: Autoimmunity

Resolving the complexity of autoimmune diseases: challenges and solutions

Chronic inflammatory diseases are life-long debilitating illnesses with increased mortality and high healthcare costs for therapy and care. These are systemic conditions characterized by activation of either the adaptive immune system—rheumatoid arthritis, lupus, multiple sclerosis— or the innate immune system—Crohn’s...

/ September 16, 2019

Q&A with Dr. Maureen McGargill, PhD: The Immune System’s Fine Line Between Health and Harm

Dr. McGargill earned her PhD at the University of Minnesota in Dr. Kristin Hogquist’s lab. There she studied T cell development, focusing on how autoreactive T cells are deleted during development. As a postdoc at the University of California, San...

“In sickness and in health”: how individual immune response variability in health may influence how we respond to illness and therapy.

Thomas Fuller once said:  "Health is not valued till sickness comes." Well, that may not be true anymore. It turns out that the key to successful disease management strategies may lie with a better understanding of individual immune response variabilities...

/ July 29, 2019

Identifying Signaling Pathways and Biomarkers in Autoimmune Diseases

As efforts in developing targeted therapies for autoimmune disease are rapidly advancing in basic research, scientists aim to validate immunology-relevant signaling pathways and uncover new intracellular molecules as potential drug targets. The NanoString® nCounter® Autoimmune Profiling and Immunology panels are...

/ June 24, 2019

Q&A with Dr. Oliver Brain: Unintended Consequences Create a Unique Opportunity to Study Inflammatory Bowel Disease.

Oliver Brain, MRCP, PhD, is a principal investigator at the University of Oxford, Nuffield Department of Clinical Medicine, and a recent winner of an nCounter® Autoimmune Profiling Panel through a NanoString® Grant Program. He took time out from treating patients...